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Characterization of plasma triiodophenol binding proteins in vertebrates and tissue distribution of triiodophenol in Rana catesbeiana tadpoles
http://hdl.handle.net/10297/5620
http://hdl.handle.net/10297/562068b9971f-5ac7-403e-91c0-763033884ff5
名前 / ファイル | ライセンス | アクション |
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110422001.pdf (599.7 kB)
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Item type | 学術雑誌論文 / Journal Article_01(1) | |||||||
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公開日 | 2011-04-22 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Characterization of plasma triiodophenol binding proteins in vertebrates and tissue distribution of triiodophenol in Rana catesbeiana tadpoles | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
Yamauchi, Kiyoshi
× Yamauchi, Kiyoshi
WEKO
4410
× Sai, Gobun |
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書誌情報 |
en : Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 巻 153, 号 3, p. 328-335, 発行日 2011-04 |
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出版者 | ||||||||
言語 | en | |||||||
出版者 | Elsevier | |||||||
権利情報 | ||||||||
権利情報 | Copyright © 2010 Elsevier Inc. All rights reserved. | |||||||
NDC | ||||||||
主題Scheme | NDC | |||||||
主題 | 464 | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | We investigated the interaction of 2,4,6-triiodophenol (TIP), a potent thyroid hormone disrupting chemical, with serum proteins from rainbow trout (Onchorhynchus mykiss), bullfrog (Rana catesbeiana), chicken (Gallus gallus), pig (Sus scrofa domesticus), and rat (Rattus norvegicus) using a [(125)I]TIP binding assay, gel filtration chromatography, and native polyacrylamide gel electrophoresis. [(125)I]TIP bound non-specifically to proteins in trout serum, specifically but weakly to proteins in bullfrog serum, and specifically and strongly to proteins in chicken, pig, and rat serum samples. Candidate TIP-binding proteins included lipoproteins (220-320kDa) in trout, albumin in bullfrog, albumin and transthyretin (TTR) in chicken and pig, and TTR in rat. TTR in the chicken, pig, and rat serum samples was responsible for the high-affinity, low-capacity binding sites for TIP (dissociation constant 2.2-3.5×10(-10)M). In contrast, a weak interaction of [(125)I]TIP with tadpole serum proteins accelerated [(125)I]TIP cellular uptake in vitro. Intraperitoneal injection of [(125)I]TIP in tadpoles revealed that the radioactivity was predominantly accumulated in the gallbladder and the kidney. The differences in the molecular and binding properties of TIP binding proteins among vertebrates would affect in part the cellular availability, tissue distribution and clearance of TIP. | |||||||
言語 | en | |||||||
ISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 15320456 | |||||||
NII書誌ID | ||||||||
収録物識別子タイプ | NCID | |||||||
収録物識別子 | AA11504679 | |||||||
PubMed番号 | ||||||||
関連タイプ | isVersionOf | |||||||
識別子タイプ | PMID | |||||||
関連識別子 | 21147258 | |||||||
出版者DOI | ||||||||
関連タイプ | isVersionOf | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | 10.1016/j.cbpc.2010.12.003 | |||||||
フォーマット | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | application/pdf | |||||||
著者版フラグ | ||||||||
出版タイプ | AM | |||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
出版者版 | ||||||||
関連タイプ | isVersionOf | |||||||
識別子タイプ | URI | |||||||
関連識別子 | https://doi.org/10.1016/j.cbpc.2010.12.003 |