{"created":"2023-07-25T10:33:17.860949+00:00","id":4669,"links":{},"metadata":{"_buckets":{"deposit":"35d34989-ca19-4578-b2d3-6e9e3dd2286c"},"_deposit":{"created_by":3,"id":"4669","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4669"},"status":"published"},"_oai":{"id":"oai:shizuoka.repo.nii.ac.jp:00004669","sets":["80:222"]},"author_link":["4519","2910","2907","2916","4520"],"item_26_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"64","bibliographicPageStart":"57","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"Journal of industrial microbiology & biotechnology"}]}]},"item_26_description_30":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_26_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"An oxalate-resistant strain of Ashbya gossypii was naturally isolated from spores grown on an oxalate-containing medium, and its medium was optimized to improve riboflavin production. Riboflavin production by the resistant strain was three-fold higher than that by the wild-type organism when grown in flask cultures. Medium optimization increased the riboflavin production by the resistant strain to 5 g l(-1), which was five-fold higher than that obtained by the wild-type strain. The productivity was reproduced in a 3-l bioreactor. During the early growth phase, the specific activity of isocitrate lyase in the oxalate-resistant strain was slightly higher than that in the wild-type strain. Proteomic analysis of the oxalate-resistant strain revealed that the expression of aldose reductase and cobalamin-independent methionine synthase decreased significantly. This is the first report that describes the natural isolation of a riboflavin producer using an antimetabolite-containing medium to enhance the riboflavin production level. This method should also be useful for improving the productivity of other bioproducts since it does not require any mutations or genetic modifications of the microorganism.","subitem_description_type":"Abstract"}]},"item_26_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_26_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"19826846","subitem_relation_type_select":"PMID"}}]},"item_26_relation_28":{"attribute_name":"出版者DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s10295-009-0647-3","subitem_relation_type_select":"DOI"}}]},"item_26_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"The original publication is available at www.springerlink.com"}]},"item_26_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13675435","subitem_source_identifier_type":"ISSN"}]},"item_26_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"14765535","subitem_source_identifier_type":"ISSN"}]},"item_26_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11132053","subitem_source_identifier_type":"NCID"}]},"item_26_subject_8":{"attribute_name":"NDC","attribute_value_mlt":[{"subitem_subject":"474","subitem_subject_scheme":"NDC"}]},"item_26_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sugimoto, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morimoto, Aki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nariyama, Masashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Tatsuya"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Park, Enoch Y."}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-14"}],"displaytype":"detail","filename":"100702002.pdf","filesize":[{"value":"392.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"100702002.pdf","url":"https://shizuoka.repo.nii.ac.jp/record/4669/files/100702002.pdf"},"version_id":"7b66f339-c60c-42b2-8890-32c4cab3214f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bioreactors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Biotechnology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Culture Media","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug Resistance, Fungal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fungal Proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Industrial Microbiology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Isocitrate Lyase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Kinetics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxalic Acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Proteome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Riboflavin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Saccharomycetales","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Spores, Fungal","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Isolation of an oxalate-resistant Ashbya gossypii strain and its improved riboflavin production","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Isolation of an oxalate-resistant Ashbya gossypii strain and its improved riboflavin production","subitem_title_language":"en"}]},"item_type_id":"26","owner":"3","path":["222"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-07-02"},"publish_date":"2010-07-02","publish_status":"0","recid":"4669","relation_version_is_last":true,"title":["Isolation of an oxalate-resistant Ashbya gossypii strain and its improved riboflavin production"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-02-14T02:51:03.391977+00:00"}