@article{oai:shizuoka.repo.nii.ac.jp:00004835, author = {Okazaki, Mariko and Nimitkeatkai, Hataitip and Muramatsu, Taku and Aoyama, Hikaru and Ueno, Kotomi and Mizutani, Masaharu and Hirai, Nobuhiro and Kondo, Satoru and Ohnishi, Toshiyuki and Todoroki, Yasushi}, issue = {1}, journal = {Bioorganic & Medicinal Chemistry}, month = {Jan}, note = {application/pdf, We developed abscinazole-E1 (Abz-E1), a specific inhibitor of abscisic acid (ABA) 8'-hydroxylase (CYP707A). This inhibitor was designed and synthesized as an enlarged analogue of uniconazole (UNI), a well-known plant growth retardant, which inhibits a gibberellin biosynthetic enzyme (ent-kaurene oxidase, CYP701A) as well as CYP707A. Our results showed that Abz-E1 functions as a potent inhibitor of CYP707A and a poor inhibitor of CYP701A both in vitro and in vivo. Abz-E1 application to plants resulted in improved desiccation tolerance and an increase in endogenous ABA.}, pages = {406--413}, title = {Abscinazole-E1, a novel chemical tool for exploring the role of ABA 8'-hydroxylase CYP707A.}, volume = {19}, year = {2011} }