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Studies on sea snake venom
http://hdl.handle.net/10297/5600
http://hdl.handle.net/10297/5600f12f690b-9be6-4157-81fb-c9181337dbc7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
110413001.pdf (564.3 kB)
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| Item type | 学術雑誌論文 / Journal Article_01(1) | |||||||
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| 公開日 | 2011-04-13 | |||||||
| タイトル | ||||||||
| タイトル | Studies on sea snake venom | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 |
Tamiya, Nobuo
× Tamiya, Nobuo× Yagi, Tatsuhiko
WEKO
2179
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| 書誌情報 |
en : Proceedings of the Japan Academy. Series B 巻 87, 号 3, p. 41-52, 発行日 2011 |
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| 出版者 | ||||||||
| 出版者 | The Japan Academy | |||||||
| 言語 | en | |||||||
| 権利情報 | ||||||||
| 権利情報 | © 2011 The Japan Academy | |||||||
| NDC | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 464 | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Erabutoxins a and b are neurotoxins isolated from venom of a sea snake Laticauda semifasciata (erabu-umihebi). Amino acid sequences of the toxins indicated that the toxins are members of a superfamily consisting of short and long neurotoxins and cytotoxins found in sea snakes and terrestrial snakes. The short neurotoxins to which erabutoxins belong act by blocking the nicotinic acetylcholine receptor on the post synaptic membrane in a manner similar to that of curare. X-ray crystallography and NMR analyses showed that the toxins have a three-finger structure, in which three fingers made of three loops emerging from a dense core make a gently concave surface of the protein. The sequence comparison and the location of essential residues on the protein suggested the mechanism of binding of the toxin to the acetylcholine receptor. Classification of snakes by means of sequence comparison and that based on different morphological features were inconsistent, which led the authors to propose a hypothesis "Evolution without divergence."(Communicated by Satoshi OMURA, M.J.A.). | |||||||
| 言語 | en | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 03862208 | |||||||
| EISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 13492896 | |||||||
| 出版者DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.2183/pjab.87.41 | |||||||
| NII論文ID | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | NAID | |||||||
| 関連識別子 | 130000669109 | |||||||
| NII書誌ID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00785485 | |||||||
| PubMed番号 | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 21422738 | |||||||
| フォーマット | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | application/pdf | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
